KPV is the C-terminal tripeptide fragment of α-MSH, used in preclinical models investigating NF-κB signaling, cytokine regulation, and inflammatory pathways.

KPV (Lys-Pro-Val) corresponds to residues 11-13 of α-melanocyte-stimulating hormone and is supplied for investigational and in vitro research use. In laboratory models it retains the anti-inflammatory activity attributed to the parent hormone while lacking the receptor-mediated pigmentation activity of full-length α-MSH.

In preclinical and laboratory research models, KPV has been examined for cellular uptake via the PepT1 transporter and for downstream inhibition of NF-κB nuclear translocation, with associated reductions in pro-inflammatory cytokine expression. These characteristics have made it a compound of interest in experimental studies focused on mucosal inflammation, epithelial barrier integrity, and immune signaling mechanisms.

Mechanism of Interest

• NF-κB Modulation: Studied for inhibition of NF-κB nuclear translocation at nanomolar concentrations.
• Cytokine Regulation: Evaluated for effects on TNF-α, IL-6, and IL-1β expression in cell models.
• PepT1 Uptake: Examined as a substrate of the peptide transporter PepT1.

Key Research Applications

• Inflammation pathway modeling
• Immune signaling research
• Epithelial barrier and mucosal studies
• Melanocortin fragment structure-activity research

Research Use Only

This product is supplied strictly for laboratory, research, and development use. Not for human consumption or therapeutic application.