MOTS-c is a research peptide used in preclinical laboratory models involving metabolic, mitochondrial, immune, or regenerative pathways.

What is it?

MOTS-c is a mitochondria-derived peptide encoded within the mitochondrial genome and studied in investigational and in vitro research settings for its role in cellular metabolic signaling. Unlike nuclear-encoded peptides, MOTS-c originates from mitochondrial DNA, positioning it as a unique signaling molecule in mitochondrial-to-nuclear communication pathways.

In preclinical and laboratory research models, MOTS-c has been examined for its influence on energy sensing pathways, insulin-related metabolic signaling, and cellular stress adaptation. These characteristics have made it a compound of interest in experimental studies exploring mitochondrial regulation, metabolic flexibility, and adaptive cellular responses to energetic demand.

Mechanism of Interest

• Mitochondrial-Derived Peptide — Studied as a 16-amino-acid peptide encoded within mitochondrial DNA (MT-RNR1).
• AMPK Signaling — Investigated for influence on AMP-activated protein kinase activity in vitro.
• Folate Cycle — Examined for interaction with methionine-folate metabolism in cell models.

Key Research Applications

• Mitochondrial-derived peptide research
• Metabolic regulation studies
• Energy homeostasis modeling

HANDLING & STORAGE

Lyophilized: Store at –20°C, protect from light and moisture.

Reconstituted: Store at 2–8°C, avoid freeze–thaw cycles.

RESEARCH USE ONLY

This product is supplied strictly for laboratory, research, and development use. Not for human consumption or therapeutic application.