Adamax is an acetylated Semax-derived nonapeptide used in preclinical models investigating BDNF signaling, neurotrophic support, and cognitive pathway modeling.

Adamax (Ac-Met-Glu-His-Phe-Pro-Gly-Pro-Ala-Gly-OH) is a synthetic analog of Semax - itself derived from the ACTH(4-10) fragment - extended at the C-terminus and acetylated at the N-terminus for investigational and in vitro research use. The modifications were introduced to improve metabolic stability and extend activity relative to the parent sequence.

In preclinical and laboratory research models, Adamax has been examined for its influence on brain-derived neurotrophic factor (BDNF) expression, TrkB receptor signaling, and neuronal resilience under cellular stress conditions. These characteristics have made it a compound of interest in experimental studies focused on neurotrophic signaling, memory pathway modeling, and neuroprotection mechanisms.

Mechanism of Interest

• Neurotrophic Signaling: Studied for effects on BDNF expression and TrkB receptor pathways.
• Melanocortin-Derived Core: Retains the ACTH(4-10) sequence shared with Semax.
• Metabolic Stability: N-terminal acetylation examined for resistance to aminopeptidase cleavage.

Key Research Applications

• Neurotrophic signaling research
• Cognitive and memory pathway modeling
• Neuroprotection and cellular stress studies
• Peptide stability and structure-activity research

Research Use Only

This product is supplied strictly for laboratory, research, and development use. Not for human consumption or therapeutic application.