Dihexa is an angiotensin IV-derived peptide analog used in preclinical models investigating hepatocyte growth factor (HGF) signaling, synaptogenesis, and neural connectivity.

Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide) is a metabolically stabilized analog of the angiotensin IV fragment, developed for investigational and in vitro research use. Its N-terminal acylation and C-terminal amidation were introduced to increase lipophilicity and resistance to enzymatic degradation relative to the parent peptide.

In preclinical and laboratory research models, Dihexa has been examined for its interaction with the HGF/c-Met receptor axis and for downstream effects on dendritic spine formation, synaptic density, and hippocampal signaling. These characteristics have made it a compound of interest in experimental studies focused on neuroplasticity, cognitive pathway modeling, and neural repair mechanisms.

Mechanism of Interest

• HGF/c-Met Signaling: Studied as a positive modulator of the hepatocyte growth factor receptor pathway.
• Synaptogenesis: Evaluated in models of dendritic spine formation and synaptic density.
• Metabolic Stability: Structurally modified for resistance to peptidase degradation in experimental systems.

Key Research Applications

• Neuroplasticity and synaptogenesis research
• Cognitive pathway modeling
• Growth-factor receptor signaling studies
• Neural repair and connectivity research

Research Use Only

This product is supplied strictly for laboratory, research, and development use. Not for human consumption or therapeutic application.