PE-22-28 is a research peptide used in preclinical laboratory models involving metabolic, mitochondrial, immune, or regenerative pathways.

What is it?

PE-22-28 is a synthetic peptide fragment corresponding to amino acids 22–28 of pancreatic polypeptide, developed for investigational and in vitro research use. It is studied as a selective signaling fragment rather than a full-length metabolic hormone.

In preclinical and laboratory research models, PE-22-28 has been examined for its interaction with neuroendocrine and hypothalamic signaling pathways involved in appetite regulation and energy balance. Its fragment-specific activity has made it a compound of interest in experimental studies exploring satiety signaling, feeding behavior modulation, and central metabolic communication mechanisms.

Mechanism of Interest

• TREK-1 Channel Blockade — Studied for inhibition of the TREK-1 potassium channel in vitro.
• Spadin Derivative — Investigated as a shortened analog of the propeptide-derived spadin sequence.
• Neurogenesis Models — Examined for effects on hippocampal neurogenesis markers in preclinical research.

Key Research Applications

• Ion channel research
• Neuroplasticity pathway modeling
• Neurogenesis studies

HANDLING & STORAGE

Lyophilized: Store at –20°C, protect from light and moisture.

Reconstituted: Store at 2–8°C, avoid freeze–thaw cycles.

RESEARCH USE ONLY

This product is supplied strictly for laboratory, research, and development use. Not for human consumption or therapeutic application.